This commentary, published ahead of print in the Journal of the American Board of Family Medicine, presents a research agenda for studying changes to primary care in community health centers as a result of the COVID-19 pandemic.

COVID-19 uncovered the holes in our fragmented healthcare system and the inequities in our society; PBRNs and the primary care practices within them can have a greater impact in reducing health inequities. The pandemic and primary care’s response to it are arguably among the most impactful natural experiments in our lifetime, presenting an unprecedented opportunity to demonstrate PBRNs’ power and value in supporting cutting-edge D&I science. We describe the OCHIN PBRN of community health centers and its partnership with implementation scientists in the BRIDGE-C2 Center. The example of how the BRIDGE-C2 Center is partnering with the OCHIN PBRN to rapidly respond to the need to study what is happening in this historic moment is presented to help other PBRNs chart a course through this pandemic.